(±)-BI-D
Product Sizes
10 mg
£ POA
HY-18601-10MG
50 mg
£ POA
HY-18601-50MG
100 mg
£ POA
HY-18601-100MG
5 mg
£ POA
HY-18601-5MG
10mM/1mL
£ POA
HY-18601-10MM
25 mg
£ POA
HY-18601-25MG
About this Product
- SKU:
- HY-18601
- CAS Number:
- 1416258-16-6
- Extra Details:
- (±)-BI-D is a potent ALLINI (allosteric integrase inhibitor). (±)-BI-D binds integrase at the LEDGF/p75 binding site. (±)-BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 μM in Psip1 knockout E9 mouse embryonic fibroblasts; 2.9 μM in wild-type E9 mouse embryonic fibroblasts)[1][2].
- Molecular Weight:
- 405.49
- Purity:
- 98.06
- References:
- [1]Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):11518-30.|[2]Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.
- Research Area:
- Infection
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Metabolic Enzyme/Protease
