SK-129
Product Sizes
Get quote
£ POA
HY-182893-1EACH
About this Product
- SKU:
- HY-182893
- CAS Number:
- 1919889-97-6
- Extra Details:
- SK-129 is a blood-brain barrier-permeable inhibitor of α-synuclein (αS) oligomers with a Kd of 221 nM. SK-129 preferentially binds to neurotoxic αS oligomers over physiological αS monomers; inhibits αS aggregation; blocks the interaction and co-aggregation of αS with tau protein; and prevents the maturation of αS-tau condensates into amyloid aggregates. SK-129 reduces ROS production; rescues dopaminergic neuron degeneration; improves motor function; restores endogenous dopamine synthesis; increases the number of Tyrosine Hydroxylase-positive neurons; prevents brain histopathological changes; alleviates neuroinflammation; and improves survival rates in relevant models. SK-129 can be used in research related to Parkinson's disease (PD) and Lewy body dementia (LBD)[1].
- Molecular Weight:
- 1006.92
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
