Caspase-3/7 activator 4
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HY-181163-1EACH
About this Product
- SKU:
- HY-181163
- Extra Details:
- Caspase-3/7 activator 4 is a caspase-3 activator and caspase-7 activator. Caspase-3/7 activator 4 inhibits key enzymes in estrogen biosynthesis; including aromatase (IC50 = 38.3 nM) and steroid sulfatase (IC50 = 12.7 µM); and selectively suppresses COX-2 (IC50 = 5.38 µM). Caspase-3/7 activator 4 shows strong antioxidant activity (DPPH: IC50 = 16.26 µM). Caspase-3/7 activator 4 inhibits estrogen synthesis; suppresses estrogen availability; reduces prostaglandin production; increases caspase-3/7 expression; induces G0/G1 cell cycle arrest; induces apoptotic cell death; reduces circulating TNF-α and VEGFR-II levels; restores hepatorenal function markers and histoarchitecture; restores antioxidant defense enzyme activity; reduces lipid peroxidation; exerts antiproliferative activity against breast cancer cells; exerts antitumor activity in the Ehrlich ascites carcinoma models. Caspase-3/7 activator 4 can be used for the research of breast cancer; ehrlich ascites carcinoma[1].
- Molecular Weight:
- 355.80
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
