CDK8-IN-20
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HY-180124-1EACH
About this Product
- SKU:
- HY-180124
- Extra Details:
- CDK8-IN-20 (Compound 67j) is a selective; potent and orally active type I CDK8 inhibitor with an IC50 of 70.5 nM. CDK8-IN-20 shows IC50 values of 147.8; 726.9 and 217.4 nM for homologous kinase CDK19; CDK7 and CDK9. CDK8-IN-20 can inhibit the Wnt/β-catenin pathway and downregulate the expression of β-catenin; Cyclin D1; and c-Myc. CDK8-IN-20 can induce ROS production and cause G2/M and S phase arrest. CDK8-IN-20can be used for the research of cancer; such as colon cancer[1].
- Molecular Weight:
- 469.51
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
