CZL-S092
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HY-176734-1EACH
About this Product
- SKU:
- HY-176734
- Extra Details:
- CZL-S092 is a PLK4 inhibitor with an IC50 value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1; PLK2; and PLK3). CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells; IC50 = 1.143 μM). CZL-S092 inhibits cell migration and halts the cell cycle and induces apoptosis. CZL-S092 can be used in studies of various cancers including neuroblastoma cancer[1].
- Molecular Weight:
- 418.49
- References:
- [1]Liu N et al. Rational design of CZL-S092: A novel indazole-based PLK4 inhibitor targeting neuroblastoma through virtual screening and fragment-based drug design strategies. Eur J Med Chem. 2025 Jun 13;296:117867. doi: 10.1016
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
