KMR-206
Product Sizes
1 mg
£ POA
HY-17663-1MG
25 mg
£ POA
HY-17663-25MG
5 mg
£ POA
HY-17663-5MG
10 mg
£ POA
HY-17663-10MG
About this Product
- SKU:
- HY-17663
- CAS Number:
- 2992741-10-1
- Extra Details:
- KMR-206 is a PARP7 inhibitor with an IC50 of 13.7 nM. KMR-206 relieves AHR-mediated transcriptional repression and enhances CYP1A1 expression in the presence of TCDD. KMR-206 induces the STING-dependent IFN-β signaling pathway and increases the levels of STAT1; pSTAT1 and nuclear PARP7 in cancer cells. KMR-206 reduces the viability of lung adenocarcinoma cells; enhances radiation-induced immunogenic signals; and induces the production of immunogenic signals in glioblastoma cancer stem cells. KMR-206 destabilizes FRA1 to increase IRF1 levels and promotes the IRF3-CBP/p300 interaction. KMR-206 can be used in studies related to lung adenocarcinoma and glioblastoma[1][2].
- Molecular Weight:
- 506.53
- Purity:
- 98.86
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
