(2S;3R;4S)-ASX-173
Product Sizes
5 mg
£ POA
HY-175282A-5MG
10 mg
£ POA
HY-175282A-10MG
25 mg
£ POA
HY-175282A-25MG
50 mg
£ POA
HY-175282A-50MG
About this Product
- SKU:
- HY-175282A
- CAS Number:
- 2748800-07-7
- Extra Details:
- (2S;3R;4S)-ASX-173 is the (2S;3R;4S)-enantiomer of ASX-173 (HY-175282). ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 μM; Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest; apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; and other cancers[1].
- Molecular Weight:
- 475.55
- Purity:
- 99.29
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
