Bumetanide (sodium)
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HY-17468A-1EACH
About this Product
- SKU:
- HY-17468A
- Additional Names:
- Ro 10-6338 (sodium); PF 1593 (sodium)
- Application:
- Electron Microscopy
- CAS Number:
- 28434-74-4
- Extra Details:
- Bumetanide sodium; a highly potent loop diuretic; is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor; and also inhibits NKCC2; with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A; respectively[1][2].
- Molecular Weight:
- 386.40
- References:
- [1]Lykke K, et al. The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Epilepsy Behav. 2016 Jun;59:42-9.|[2]Ciaran Richardson, et al. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011 Mar 1;124(Pt 5):789-800.|[3]Martha E O'Donnell, et al. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab. 2004 Sep;24(9):1046-56.|[4]S H Lee, et al. Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to rats: absorption from various GI segments. J Pharmacokinet Biopharm. 1994 Feb;22(1):1-17.6
- Research Area:
- Metabolic Disease; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
