Bumetanide
Product Sizes
1 g
£ POA
HY-17468-1G
500 mg
£ POA
HY-17468-500MG
10 g
£ POA
HY-17468-10G
5 g
£ POA
HY-17468-5G
10mM/1mL
£ POA
HY-17468-10MM
About this Product
- SKU:
- HY-17468
- Additional Names:
- Ro 10-6338; PF 1593
- CAS Number:
- 28395-03-1
- Extra Details:
- Bumetanide (Ro 10-6338; PF 1593); a highly potent loop diuretic; is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor; but also inhibits NKCC2; with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A; respectively[1][2].
- Molecular Weight:
- 364.42
- Purity:
- 99.95
- References:
- [1]Lykke K, et al. The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Epilepsy Behav. 2016 Jun;59:42-9.|[2]Ciaran Richardson, et al. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011 Mar 1;124(Pt 5):789-800.|[3]Martha E O'Donnell, et al. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab. 2004 Sep;24(9):1046-56.|[4]S H Lee, et al. Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to rats: absorption from various GI segments. J Pharmacokinet Biopharm. 1994 Feb;22(1):1-17.6
- Research Area:
- Metabolic Disease; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel
