(1S;2R)-Tranylcypromine-d5 (hydrochloride)
Product Sizes
1 mg
£ POA
HY-17447AS-1MG
About this Product
- SKU:
- HY-17447AS
- Additional Names:
- (1S;2R)-SKF 385-d5 (hydrochloride)
- Extra Details:
- (1S;2R)-Tranylcypromine-d5 (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1; MAO A and MAO B with IC50s of 20.7; 2.3 and 0.95 μM; respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].
- Molecular Weight:
- 174.68
- References:
- [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Lee MG, et al. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006 Jun;13(6):563-7.|[3]Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46(14):4408-16.|[4]Park H, et al. The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD. Cells. 2020 Aug 28;9(9):1982.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
