2-5A
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HY-173189-1EACH
About this Product
- SKU:
- HY-173189
- Additional Names:
- 2′;5′-ApApA; 2′;5′-trioligoadenylate; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine
- CAS Number:
- 65954-93-0
- Extra Details:
- 2-5A is a RNase L activator; signal mediator and innate immune second messenger. 2-5A induces the expression of interferons and interferon-stimulated genes in recipient cells in a RNase L-dependent manner. 2-5A inhibits tumor growth in mouse models via paracrine RNase L activation derived from cancer cells. 2-5A can be used in studies related to viral infection and cancer[1].
- Molecular Weight:
- 1165.59
- References:
- [1]Kalinichenko EN, et al. 3'-Fluoro-3'-deoxy analogs of 2-5A 5'-monophosphate: binding to 2-5A-dependent endoribonuclease and susceptibility to (2'-5')phosphodiesterase degradation. Biochem Biophys Res Commun. 1990 Feb 28;167(1):20-6.|[2]Barnard DL, Sidwell RW, Xiao W, Player MR, Adah SA, Torrence PF. 2-5A-DNA conjugate inhibition of respiratory syncytial virus replication: effects of oligonucleotide structure modifications and RNA target site selection. Antiviral Res. 1999 Apr;41(3):119-34.
- Research Area:
- Cancer;Infection
- Shipping Conditions:
- Ambient
- Type:
- Molecular Biology Reagents: Nucleic Acids
