PD-L1/HDAC6-IN-1
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HY-172200-1EACH
About this Product
- SKU:
- HY-172200
- CAS Number:
- 2834094-36-7
- Extra Details:
- PD-L1/HDAC6-IN-1 (Compound HP29) is the inhibitor for PD-L1 and HDAC6 that inhibits the PD-L1/PD-1 interaction and HDAC6 with an IC50 of 26.8 nM and 69 nM. PD-L1/HDAC6-IN-1 enhances the killing ability of Jurkat T cells against HepG2 cells with an IC50 of 3.4 μM. PD-L1/HDAC6-IN-1 exhibits good pharmacokinetics characteristics in rats with a drug exposure of 871.62 ng·h/mL; and exhibits antitumor activity in mouse B16-F10 xenograft models[1].
- Molecular Weight:
- 447.57
- References:
- [1]Hu Z, et al., Discovery of Novel and Highly Potent Dual PD-L1/Histone Deacetylase 6 Inhibitors with Favorable Pharmacokinetics for Cancer Immunotherapy. J Med Chem. 2025 Mar 13;68(5):5426-5454.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
