PD-L1/HDAC-IN-1
Product Sizes
Get quote
£ POA
HY-172167-1EACH
About this Product
- SKU:
- HY-172167
- CAS Number:
- 2923313-69-1
- Extra Details:
- PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction; HDAC2 and HDAC3 with IC50 of 88.10; 27.98 and 14.47 nM; respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10; promoting anti-tumour immune response by recruiting T-cell infiltration into TME[1].
- Molecular Weight:
- 740.28
- References:
- [1]Yuan D, et al., Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2461190.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
