1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA
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HY-171906-1EACH
About this Product
- SKU:
- HY-171906
- Additional Names:
- 1-Arachidonoyl-sn-glycerol 3-phosphate; 1-Arachidonoyl LPA; LPA (20:4)
- CAS Number:
- 65446-08-4
- Extra Details:
- 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid containing arachidonic acid at the sn-1 position. It is a precursor to 1-arachidonoyl glycerol (1-Monoarachidin; HY-130567)[1]. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM[2]. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS[3]. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate[4].
- Molecular Weight:
- 458.53
- References:
- [1]Nakane, S., Oka, S., Arai, S., et al. 2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain. Arch. Biochem. Biophys. 402(1), 51-58 (2002).|[2]Bandoh, K., Aoki, J., Taira, A., et al. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 478(1-2), 159-165 (2000).|[3]Emo, J., Meednu, N., Chapman, T.J., et al. Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation. J. Immunol. 188(8), 3784-3790 (2012).|[4]Hidaka, M., Nishihara, M., and Tokumura, A. Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells. Life Sci. 197, 73-79 (2018).
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
