AMT-562
Product Sizes
10 mg
£ POA
HY-171747-10MG
5 mg
£ POA
HY-171747-5MG
1 mg
£ POA
HY-171747-1MG
About this Product
- SKU:
- HY-171747
- Extra Details:
- AMT-562 is an antibody-drug conjugate (ADC) consisting of a novel anti-HER3 antibody Ab562 (HY-P991505) conjugated to the linker MC-VA-PAB and the topoisomerase I inhibitor Exatecan (HY-13631). The ADC toxic molecule and linker portion are MC-VA-PAB-Exatecan (HY-147270). AMT-562 can induce apoptosis and has antitumor activity against pancreatic; esophageal; and gastric cancers[1][2].
- References:
- [1]Weng W, et al. AMT-562, a Novel HER3-targeting Antibody-Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors. Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. |[2]KRAIEM, et al. Treatment of cancer. WO2021151984A1.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
