Atezolizumab-MMAE
Product Sizes
1 mg
£ POA
HY-171572-1MG
500 μg
£ POA
HY-171572-500UG
About this Product
- SKU:
- HY-171572
- Extra Details:
- Atezolizumab-MMAE is an anti-PD-L1 antibody-drug conjugate (ADC) with an EC50 of 1.1 nM. Atezolizumab-MMAE is composed of a humanized anti-PD-L1 antibody (Atezolizumab) (HY-P9904); a lysosomally cleavable dipeptide linker (valine-citrulline); a tubulin inhibitor (MMAE) (HY-15162); and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Atezolizumab-MMAE has a potent cytotoxicity (EC50: 9.75-11.94 nM) and immune activation effect. Atezolizumab-MMAE has a significantly anti-tumor activity in MC38 xenograft PD-1-humanized immune system mice model[1][2].
- Purity:
- 98.04
- References:
- [1]Xiao D, et al. Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation. Bioorg Chem. 2021 Nov; 116:105366.|[2]Zanello A, et al. Anti-PD-L1 immunoconjugates for cancer therapy: Are available antibodies good carriers for toxic payload delivering? Front Pharmacol. 2022 Aug 16; 13:972046.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -80[o]C; protect from light
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
