AR antagonist 10
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HY-170951-1EACH
About this Product
- SKU:
- HY-170951
- CAS Number:
- 3068489-78-8
- Extra Details:
- AR antagonist 10 (Compound Y5) is potent and orally active androgen receptor (AR) antagonist with an IC50 of 0.04 μM. AR antagonist 10 demonstrates dual mechanisms of action; antagonizes AR by disrupting AR dimerization; and induces AR degradation via the ubiquitin-proteasome pathway. AR antagonist 10 exhibits excellent activity against variant drug-resistant AR mutants. AR antagonist 10 effectively suppresses the tumor growth of the LNCaP xenograft. AR antagonist 10 is potential to be used for drug-resistant prostate cancer[1].
- Molecular Weight:
- 404.87
- References:
- [1]Jianing Liao, et al. Discovery of N‑(1,2,4-Thiadiazol-5-yl)benzo[b]oxepine-4-carboxamide Derivatives as Novel Antiresistance Androgen Receptor Antagonists. Journal of Medicinal Chemistry 2025 68 (3), 3445-3459.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
