Agomelatine (L(+)-Tartaric acid) (Standard)
Product Sizes
Agomelatine (L(+)-Tartaric acid) (Standard)
£ POA
HY-17038BR
About this Product
- SKU:
- HY-17038BR
- CAS Number:
- 824393-18-2
- Extra Details:
- Agomelatine (L(+)-Tartaric acid) (Standard) is the analytical standard of Agomelatine (L(+)-Tartaric acid). This product is intended for research and analytical applications. Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].
- Molecular Weight:
- 393.39
- References:
- [1]Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61.|[2]Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64.|[3]Aguiar CC, et al. Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol. 2013 Aug;33(6):825-35.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
