GNE-3500
Product Sizes
25 mg
£ POA
HY-16983-25MG
10 mg
£ POA
HY-16983-10MG
5 mg
£ POA
HY-16983-5MG
About this Product
- SKU:
- HY-16983
- CAS Number:
- 1537859-24-7
- Extra Details:
- GNE-3500 is a selective; orally active antagonist for Retinoic Acid Receptor-Related Orphan Receptor C (RORc; also known as RORγ or NR1F3) with an EC50 of 12 nM. GNE-3500 exhibits good pharmacokinetic characteristics in rats[1].
- Molecular Weight:
- 459.58
- Purity:
- 98.90
- References:
- [1]Fauber BP, et al., Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist. J Med Chem. 2015 Jul 9;58(13):5308-22.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
