Dihexa
Product Sizes
25 mg
£ POA
HY-16969-25MG
100 mg
£ POA
HY-16969-100MG
2 mg
£ POA
HY-16969-2MG
5 mg
£ POA
HY-16969-5MG
10 mg
£ POA
HY-16969-10MG
50 mg
£ POA
HY-16969-50MG
1 g
£ POA
HY-16969-1G
10mM/1mL
£ POA
HY-16969-10MM
About this Product
- SKU:
- HY-16969
- Additional Names:
- PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2
- CAS Number:
- 1401708-83-5
- Extra Details:
- Dihexa; an oligopeptide drug; is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor; c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease[1][2].
- Molecular Weight:
- 504.66
- Purity:
- 98.92
- References:
- [1]Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402.|[2]McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Protein Tyrosine Kinase/RTK
