(E/Z)-4-Hydroxytamoxifen
Product Sizes
50 mg
£ POA
HY-16950A-50MG
10 mg
£ POA
HY-16950A-10MG
100 mg
£ POA
HY-16950A-100MG
5 mg
£ POA
HY-16950A-5MG
10mM/1mL
£ POA
HY-16950A-10MM
About this Product
- SKU:
- HY-16950A
- Additional Names:
- Afimoxifene; 4-OHT
- Application:
- Antibody Microarray
- CAS Number:
- 68392-35-8
- Extra Details:
- (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity; which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia; such as breast pain; tenderness; and nodularity[1][2][3][4].
- Molecular Weight:
- 387.51
- Purity:
- 99.62
- References:
- [1]Mansel R, et al. A phase II trial of Afimoxifene (4-hydroxytamoxifen gel) for cyclical mastalgia in premenopausal women. Breast Cancer Res Treat. 2007 Dec;106(3):389-97. |[2]Desta Z, et al. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.|[3]Gamboa da Costa G, et al. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives. Carcinogenesis. 2001 Aug;22(8):1307-15. |[4]Prossnitz ER, et al. International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacol Rev. 2015 Jul;67(3):505-40.
- Research Area:
- Cancer; Metabolic Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
