(5aS;6R;6aR)-MK-8666
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HY-168168-1EACH
About this Product
- SKU:
- HY-168168
- Application:
- Electron Microscopy
- CAS Number:
- 1544739-76-5
- Extra Details:
- (5aS;6R;6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS;6R;6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS;6R;6aR)-MK-8666 is considered to have potential inhibitory advantages; its development was stopped in Phase I clinical trials due to liver safety issues[1].
- Molecular Weight:
- 521.62
- References:
- [1]Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester
- Research Area:
- Metabolic Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
