CDD-1653
Product Sizes
50 mg
£ POA
HY-164145-50MG
10 mg
£ POA
HY-164145-10MG
100 mg
£ POA
HY-164145-100MG
25 mg
£ POA
HY-164145-25MG
5 mg
£ POA
HY-164145-5MG
10mM/1mL
£ POA
HY-164145-10MM
About this Product
- SKU:
- HY-164145
- CAS Number:
- 3034216-44-6
- Extra Details:
- CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2; thereby affecting the phosphorylation of SMAD1/5/8 transcription factors; which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1].
- Molecular Weight:
- 454.50
- Purity:
- 99.38
- References:
- [1]Modukuri R K, et al. Discovery of highly potent and BMPR2-selective kinase inhibitors using DNA-encoded chemical library screening[J]. Journal of Medicinal Chemistry, 2023, 66(3): 2143-2160.
- Research Area:
- Cancer; Others
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- TGF-beta/Smad
