PROTAC PD-L1 degrader-1
Product Sizes
1 mg
£ POA
HY-163757-1MG
25 mg
£ POA
HY-163757-25MG
10 mg
£ POA
HY-163757-10MG
5 mg
£ POA
HY-163757-5MG
10mM/1mL
£ POA
HY-163757-10MM
About this Product
- SKU:
- HY-163757
- Application:
- Antibody Microarray
- CAS Number:
- 3052114-77-6
- Extra Details:
- PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer. (Blue: CRBN ligand (HY-150839); Black: linker; Pink: PD-L inhibitor (HY-19745))[1].
- Molecular Weight:
- 777.95
- Purity:
- 99.79
- References:
- [1]Hongjia Zhang, et al. Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem. 2024 Jun 18.
- Research Area:
- Cancer;Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Immunology/Inflammation;PROTAC
