BSJ-5-63
Product Sizes
10 mg
£ POA
HY-162706-10MG
5 mg
£ POA
HY-162706-5MG
25 mg
£ POA
HY-162706-25MG
50 mg
£ POA
HY-162706-50MG
10mM/1mL
£ POA
HY-162706-10MM
100 mg
£ POA
HY-162706-100MG
About this Product
- SKU:
- HY-162706
- CAS Number:
- 2519823-37-9
- Extra Details:
- BSJ-5-63 is a potent CDK12; CDK7; CDK9 PROTAC degrader. BSJ-5-63 BSJ-5-63 decreases the protein expression of CDK12; CDK7; CDK9; RNAPII; Cyclin K. BSJ-5-63 decreases the mRNA expression of BRCA1; BRCA2. BSJ-5-63 shows anticancer activity and has the potential for the research of prostate cancer (Pink: ligand for target protein (HY-150948); black: linker (HY-W140827); Blue: E3 ligase ligand (HY-112078))[1].
- Molecular Weight:
- 1020.78
- Purity:
- 99.97
- References:
- [1]Gui F, et al. Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer. bioRxiv [Preprint]. 2024 Jul 10:2024.07.09.602803.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store at room temperature 3 years
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;PROTAC
