(S)-DMAPT
Product Sizes
5 mg
£ POA
HY-16172A-5MG
About this Product
- SKU:
- HY-16172A
- Additional Names:
- (S)-Dimethylamino Parthenolide
- Application:
- Antibody Microarray
- CAS Number:
- 870677-05-7
- Extra Details:
- (S)-DMAPT (Dimethylamino Parthenolide); an analogue of Parthenolide (PTL); is an oral active NF-κB inhibitor; with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect[1].
- Molecular Weight:
- 293.40
- References:
- [1]Neelakantan S, et al. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett. 2009 Aug 1;19(15):4346-9.|[2]Mendonca MS, et al. DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 Nov;112:318-326.|[3]Morel KL, et al. Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide. Clin Exp Metastasis. 2018 Oct;35(7):649-661.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- NF-κB
