CBP/p300 ligand 3
Product Sizes
100 mg
£ POA
HY-161483-100MG
50 mg
£ POA
HY-161483-50MG
25 mg
£ POA
HY-161483-25MG
10 mg
£ POA
HY-161483-10MG
5 mg
£ POA
HY-161483-5MG
About this Product
- SKU:
- HY-161483
- Application:
- Antibody Microarray
- CAS Number:
- 1936425-34-1
- Extra Details:
- CBP/p300 ligand 3 is a target protein ligand of CBPD-268 (HY-161369). CBP and p300 are two proteins with histone acetyltransferase (HAT) activity; and CBP and p300 play key roles in regulating biological processes such as gene expression; cell proliferation; differentiation and DNA repair. Through its acetyltransferase activity; CBP/p300 can acetylate histones and other proteins; thereby regulating chromatin structure and gene expression. CBP/p300 ligand 3 regulates the function of CBP/p300 by binding to a specific domain of the CBP/p300 protein (the bromine domain or HAT domain); inhibiting its enzyme activity or altering its interactions with other proteins (transcription factors). CBP/p300 ligand 3 can be used in cancer; neurodegenerative diseases and other disease models associated with abnormal CBP/p300 function[1].
- Molecular Weight:
- 426.46
- Purity:
- 98.82
- References:
- [1]Chen Z, et al. Discovery of CBPD-268 as an exceptionally potent and orally efficacious CBP/p300 PROTAC degrader capable of achieving tumor regression[J]. Journal of Medicinal Chemistry, 2024, 67(7): 5275-5304.
- Research Area:
- Cancer; Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
