2-octynoic acid-BSA
Product Sizes
10 mg
HY-160719-10MG
5 mg
HY-160719-5MG
25 mg
HY-160719-25MG
About this Product
- SKU:
- HY-160719
- Extra Details:
- NHS-activated 2-octynoic acid-BSA is an immunogen used to establish a mouse model of primary biliary cholangitis (PBC). When used in combination with Complete Freund's Adjuvant (HY-153808); NHS-activated 2-octynoic acid-BSA stimulates the body's immune system; which recognizes it as a foreign antigen and triggers an immune response against autologous biliary epithelial cells. This leads to the production of anti-PDC-E2 antibodies; causing bile duct damage and inflammation. NHS-activated 2-octynoic acid-BSA is promising for use in primary biliary cholangitis research[1].
- Molecular Weight:
- 69068 (average)
- Purity:
- 97.09
- References:
- [1]Wakabayashi K, et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008 Aug;48(2):531-40.|[2]Liu B, et al. Depletion of Natural Killer Cells improve cholestasis in a murine model of primary biliary cholangitis[J]. 2023.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -80[o]C; protect from light
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
