(Rac)-AAA
Product Sizes
500 μg
£ POA
HY-160187A-500UG
1 mg
£ POA
HY-160187A-1MG
About this Product
- SKU:
- HY-160187A
- CAS Number:
- 3055022-23-3
- Extra Details:
- (Rac)-AAA is a regulator and inhibitor targeting GPR75. By blocking the 20-HETE-induced downregulation of GPR75 expression; (Rac)-AAA effectively inhibits the activation of key downstream signaling pathways including EGFR; AKT; NF-κB and FAK. (Rac)-AAA reverses 20-HETE-mediated epithelial-mesenchymal transition; which is specifically characterized by downregulating vimentin (vimentin); upregulating E-Cadherin; as well as reducing MMP-2 activity and cancer cell migration ability. (Rac)-AAA also abolishes the 20-HETE-induced upregulation of HIC-5 expression and anchorage-independent growth; and modulates the subcellular localization of PKC-α and phosphorylated AKT. (Rac)-AAA is investigated in androgen-independent prostate cancer (castration-resistant prostate cancer)[1].
- Molecular Weight:
- 483.55
- Purity:
- 99.02
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
