PD-1/PD-L1-IN-54
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HY-159892-1EACH
About this Product
- SKU:
- HY-159892
- CAS Number:
- 1393644-68-2
- Extra Details:
- PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (KD: PD-1; 55.8 μM; PD-L1; 46.4 μM; IC50: 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8+ T cells; upregulating PD-1 expression; and increasing secretion of IFN-γ and IL-2. PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis. PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1[1].
- Molecular Weight:
- 368.77
- References:
- [1]Kuang QX, et al. New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions. Bioorganic chemistry, 2024, 153, 107899.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
