Gp(2′-5′)Ap (sodium)
Product Sizes
5 mg
£ POA
HY-159857-5MG
1 mg
£ POA
HY-159857-1MG
10 mg
£ POA
HY-159857-10MG
About this Product
- SKU:
- HY-159857
- Additional Names:
- Gp(2′-5′)Ap(3′) (sodium); 2'5'-GpAp (sodium); Guanylyl-(2′→5′)-3′-adenylic acid (sodium)
- Extra Details:
- Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation; 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.
- Molecular Weight:
- 758.37
- Purity:
- 98.88
- References:
- [1]Dey RJ, Dey B, Zheng Y, et al. Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase. Nat Chem Biol. 2017;13(2):210-217.|[2]Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380-384.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; stored under nitrogen; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Others
