I1421
Product Sizes
5 mg
£ POA
HY-158991-5MG
25 mg
£ POA
HY-158991-25MG
10 mg
£ POA
HY-158991-10MG
50 mg
£ POA
HY-158991-50MG
10mM/1mL
£ POA
HY-158991-10MM
About this Product
- SKU:
- HY-158991
- CAS Number:
- 3054995-92-2
- Extra Details:
- I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency; with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor (HY-111772) to enhance CFTR currents[1].
- Molecular Weight:
- 343.35
- Purity:
- 99.15
- References:
- [1]Liu F, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674(24)00472-0.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel
