DI-1548
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HY-156240-1EACH
About this Product
- SKU:
- HY-156240
- Application:
- Electron Microscopy
- CAS Number:
- 2247060-97-3
- Extra Details:
- DI-1548 is a potent; selective; and irreversible covalent inhibitor of DCN1 (IC50 = 4.6 nM). DI-1548 potently and selectively inhibits cullin 3 neddylation at nanomolar concentrations; and exhibits no obvious effect on the neddylation of other cullin members (including cullin 1; 2; 4A; 4B; and 5). DI-1548 exhibits no cytotoxicity. DI-1548 covalently binds to DCN1; disrupting the DCN1-UBC12 interaction; causing the collapse of the neddylation complex; inactivating CRL3; leading to NRF2 accumulation and upregulation of its target genes; and ultimately protecting mice from liver damage. DI-1548 can be used in liver injury research[1].
- Molecular Weight:
- 597.81
- Research Area:
- Metabolic Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
