CYP51/PD-L1-IN-2
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HY-156150-1EACH
About this Product
- SKU:
- HY-156150
- CAS Number:
- 3032386-58-3
- Extra Details:
- CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-2 is a dual inhibitor of CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM); which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-2 also significantly reduced intracellular IL-2; NLRP3; and NF-κBp65 protein levels; induced mitochondrial damage and ROS accumulation; and ultimately led to fungal lysis and death[1].
- Molecular Weight:
- 469.50
- References:
- [1]Sun B, et al. Design, Synthesis, and Activity Evaluation of Novel Dual-Target Inhibitors with Antifungal and Immunoregulatory Properties. J Med Chem. 2023 Sep 13.. .
- Research Area:
- Infection
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
