(R)-(-)-Gossypol acetic acid
Product Sizes
100 mg
HY-15464A-100MG
50 mg
HY-15464A-50MG
5 mg
HY-15464A-5MG
10 mg
HY-15464A-10MG
25 mg
HY-15464A-25MG
About this Product
- SKU:
- HY-15464A
- Additional Names:
- AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid
- Application:
- Antibody Microarray
- CAS Number:
- 866541-93-7
- Extra Details:
- (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2; Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM; 170±10 nM; and 480±40 nM; respectively.
- Molecular Weight:
- 578.61
- Purity:
- 98.93
- References:
- [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.|[2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; protect from light; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Autophagy
