(R)-(-)-Gossypol
Product Sizes
5 mg
HY-15464-5MG
10 mg
HY-15464-10MG
25 mg
HY-15464-25MG
10mM/1mL
HY-15464-10MM
About this Product
- SKU:
- HY-15464
- Additional Names:
- AT-101; R-(-)-gossypol acetic acid
- Application:
- Antibody Microarray
- CAS Number:
- 90141-22-3
- Extra Details:
- (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2; Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM; 170±10 nM; and 480±40 nM; respectively.
- Molecular Weight:
- 518.55
- Purity:
- 99.37
- References:
- [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.|[2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Autophagy
