(S)-Selisistat
Product Sizes
10 mg
£ POA
HY-15452A-10MG
100 mg
£ POA
HY-15452A-100MG
1 mg
£ POA
HY-15452A-1MG
50 mg
£ POA
HY-15452A-50MG
25 mg
£ POA
HY-15452A-25MG
5 mg
£ POA
HY-15452A-5MG
10mM/1mL
£ POA
HY-15452A-10MM
About this Product
- SKU:
- HY-15452A
- Additional Names:
- (S)-EX-527
- Application:
- Antibody Microarray
- CAS Number:
- 848193-68-0
- Extra Details:
- (S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor; with an IC50 of 98 nM.
- Molecular Weight:
- 248.71
- Purity:
- 99.39
- References:
- [1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.|[2]Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38.|[3]Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849.|[4]Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics
