(Rac)-Rotigotine-d3 (hydrochloride)
Product Sizes
1 mg
£ POA
HY-15394S1-1MG
About this Product
- SKU:
- HY-15394S1
- Additional Names:
- N-0437-d3 (hydrochloride)
- Application:
- Electron Microscopy
- CAS Number:
- 1215846-20-0
- Extra Details:
- (Rac)-Rotigotine-d3 hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor; a partial agonist of the 5-HT1A receptor; and an antagonist of the α2B-adrenergic receptor; with Kis of 0.71 nM; 4-15 nM; and 83 nM for the dopamine D3 receptor and D2; D5; D4 receptors; and dopamine D1 receptor.
- Molecular Weight:
- 354.95
- References:
- [1]Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.|[2]Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.|[3]Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.|[4]Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.
- Research Area:
- Endocrinology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- RT; stored under nitrogen
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling;Others
