(Rac)-Rotigotine (hydrochloride) (Standard)
Product Sizes
25 mg
£ POA
HY-15394R-25MG
5 mg
£ POA
HY-15394R-5MG
50 mg
£ POA
HY-15394R-50MG
100 mg
£ POA
HY-15394R-100MG
10 mg
£ POA
HY-15394R-10MG
About this Product
- SKU:
- HY-15394R
- CAS Number:
- 102120-99-0
- Extra Details:
- (Rac)-Rotigotine (hydrochloride) (Standard) is the analytical standard of (Rac)-Rotigotine (hydrochloride). This product is intended for research and analytical applications. (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor; a partial agonist of the 5-HT1A receptor; and an antagonist of the α2B-adrenergic receptor; with Kis of 0.71 nM; 4-15 nM; and 83 nM for the dopamine D3 receptor and D2; D5; D4 receptors; and dopamine D1 receptor.
- Molecular Weight:
- 351.93
- References:
- [1]Wood M, et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35.|[2]Scheller D, et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.|[3] Fenu S, et al. In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. Eur J Pharmacol. 2016 Oct 5;788:183-91.|[4]Radad K, et al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86.
- Research Area:
- Endocrinology; Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
