GTI 2040
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HY-153834-1EACH
About this Product
- SKU:
- HY-153834
- Application:
- Antibody Microarray
- CAS Number:
- 236391-66-5
- Extra Details:
- GTI-2040; a 20-mer phosphorothioate oligonucleotide; was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.
- References:
- [1]Vassilakos A, Lee Y, Viau S, et al. GTI-2040 displays cooperative anti-tumor activity when combined with interferon alpha against human renal carcinoma xenografts. Int J Oncol. 2009;34(1):33-42.|[2]Ferdinandi ES, Vassilakos A, Lee Y, et al. Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2. Cancer Chemother Pharmacol. 2011;68(1):193-205. doi:10.1007/s00280-010-1473-z
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Molecular Biology Reagents: Nucleic Acids
