ARC19499 (sodium)
Product Sizes
10 mg
£ POA
HY-153480A-10MG
5 mg
£ POA
HY-153480A-5MG
1 mg
£ POA
HY-153480A-1MG
About this Product
- SKU:
- HY-153480A
- Additional Names:
- BAX499 (sodium)
- Application:
- Electron Microscopy
- Extra Details:
- ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) ; thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
- Molecular Weight:
- 11837.60
- Purity:
- 99.40
- References:
- [1]Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood. 2011;117(20):5514-5522.|[2]Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia. Thromb Res. 2012;130(6):948-955.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Metabolic Enzyme/Protease
