ARC19499
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HY-153480-1EACH
About this Product
- SKU:
- HY-153480
- Additional Names:
- BAX499
- Application:
- Electron Microscopy
- CAS Number:
- 1350667-54-7
- Extra Details:
- ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) ; thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
- Molecular Weight:
- 11078.95
- Purity:
- 93.65
- References:
- [1]Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood. 2011;117(20):5514-5522.|[2]Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia. Thromb Res. 2012;130(6):948-955.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
