(S)-TNG260
Product Sizes
100 mg
£ POA
HY-153358A-100MG
5 mg
£ POA
HY-153358A-5MG
25 mg
£ POA
HY-153358A-25MG
50 mg
£ POA
HY-153358A-50MG
10 mg
£ POA
HY-153358A-10MG
10mM/1mL
£ POA
HY-153358A-10MM
About this Product
- SKU:
- HY-153358A
- Application:
- Antibody Microarray
- CAS Number:
- 2935964-93-3
- Extra Details:
- (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
- Molecular Weight:
- 383.44
- Purity:
- 99.78
- References:
- [1]Ahronian L, et al. TNG260, a CoREST-selective deacetylase inhibitor, reverses anti-PD1 resistance driven by loss of STK11[J]. J Immunother, 2022, 10(2): A1-A1595.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics
