(Rac)-Reparixin
Product Sizes
5 mg
£ POA
HY-15251A-5MG
10 mg
£ POA
HY-15251A-10MG
50 mg
£ POA
HY-15251A-50MG
25 mg
£ POA
HY-15251A-25MG
2 mg
£ POA
HY-15251A-2MG
10mM/1mL
£ POA
HY-15251A-10MM
About this Product
- SKU:
- HY-15251A
- Additional Names:
- (Rac)-Repertaxin; (Rac)-DF 1681Y
- Application:
- Electron Microscopy
- CAS Number:
- 957407-64-6
- Extra Details:
- (Rac)-Reparixin is the isomer of Reparixin (HY-15251); and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM; respectively.
- Molecular Weight:
- 283.39
- Purity:
- 99.82
- References:
- [1]Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4.|[2]Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6.|[3]Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9.|[4]Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820.|[5]Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002.|[6]Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54.|[7]Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7.
- Research Area:
- Cancer; Endocrinology; Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Immunology/Inflammation
