2’-Azido-2’-deoxycytidine
Product Sizes
10 mg
£ POA
HY-152448-10MG
25 mg
£ POA
HY-152448-25MG
5 mg
£ POA
HY-152448-5MG
50 mg
£ POA
HY-152448-50MG
100 mg
£ POA
HY-152448-100MG
200 mg
£ POA
HY-152448-200MG
About this Product
- SKU:
- HY-152448
- Application:
- Antibody Microarray
- CAS Number:
- 51034-68-5
- Extra Details:
- 2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis; induction of apoptosis; etc[1]. 2’-Azido-2’-deoxycytidine is a click chemistry reagent; it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside;and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
- Molecular Weight:
- 268.23
- Purity:
- 98.78
- References:
- [1]Kang SH, Cho MJ. Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine. Nucleosides Nucleotides. 1998;17(6):1077-1088.|[2]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-3388.
- Research Area:
- Others
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage
