SL 0101-1
Product Sizes
5 mg
£ POA
HY-15237-5MG
1 mg
£ POA
HY-15237-1MG
About this Product
- SKU:
- HY-15237
- Additional Names:
- SL0101
- CAS Number:
- 77307-50-7
- Extra Details:
- SL 0101-1 (SL0101); a kaempferol glycoside; isolated from the tropical plant F. refracta; is a cell-permeable; selective; reversible; ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor; with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor; with a Ki of 1 μM[2].
- Molecular Weight:
- 516.45
- Purity:
- 98.0
- References:
- [1]Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.|[2]Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- MAPK/ERK Pathway
