(S)-Sabutoclax
Product Sizes
5 mg
£ POA
HY-15191B-5MG
10 mg
£ POA
HY-15191B-10MG
10mM/1mL
£ POA
HY-15191B-10MM
About this Product
- SKU:
- HY-15191B
- Additional Names:
- (S)-BI-97C1
- Application:
- Antibody Microarray
- CAS Number:
- 1228178-73-1
- Extra Details:
- (S)-Sabutoclax ((S)-BI-97C1); an optically pure apogossypol derivative; is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL; Bcl-2; Mcl-1; and Bfl-1 with IC50 values of 0.31; 0.32; 0.20; and 0.62 μM; respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer; lung cancer; and lymphoma cell lines with EC50 values of 0.13; 0.56; and 0.049 μM; respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer[1].
- Molecular Weight:
- 700.78
- Purity:
- 98.03
- References:
- [1]Wei J, et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27;53(10):4166-76.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis
