Ipatasertib (tosylate)
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HY-15186C-1EACH
About this Product
- SKU:
- HY-15186C
- Additional Names:
- GDC-0068 (tosylate); RG7440 (tosylate)
- CAS Number:
- 1491138-24-9
- Extra Details:
- Ipatasertib (GDC-0068) tosylate is an orally active; highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5; 18; 8 nM for Akt1/2/3; respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models[1][2].
- Molecular Weight:
- 630.20
- References:
- [1]Sun L, et al. Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis. Cell Death Dis. 2018 Sep 5;9(9):911.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
