(E/Z)-Zotiraciclib (hydrochloride)
Product Sizes
50 mg
£ POA
HY-15166A-50MG
5 mg
£ POA
HY-15166A-5MG
10 mg
£ POA
HY-15166A-10MG
100 mg
£ POA
HY-15166A-100MG
25 mg
£ POA
HY-15166A-25MG
10mM/1mL
£ POA
HY-15166A-10MM
About this Product
- SKU:
- HY-15166A
- Additional Names:
- (E/Z)-TG02 (hydrochloride); (E/Z)-SB1317 (hydrochloride)
- CAS Number:
- 1321626-25-8
- Extra Details:
- (E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2; JAK2 and FLT3 with IC50s of 13; 73 and 56 nM; respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells; it can be used for the research of cancer[1][2].
- Molecular Weight:
- 408.92
- Purity:
- 99.90
- References:
- [1]William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
