(Rac)-Lonafarnib
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HY-15136B-1EACH
About this Product
- SKU:
- HY-15136B
- Additional Names:
- Sch66336 (racemate)
- CAS Number:
- 193275-86-4
- Extra Details:
- (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras; K-ras and N-ras with IC50 values of 1.9 nM; 5.2 nM and 2.8 nM; respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].
- Molecular Weight:
- 638.82
- References:
- [1]Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56.
- Research Area:
- Cancer; Infection
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
